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ea0090p351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

High-fat diet promotes 3’mt-tiRNA-Met epididymosome enrichment which correlates to lower spermatozoa mitochondrial translation

Pereira Sara C. , Freire-Brito Lais , Guerra-Carvalho Barbara , Carrageta David F. , Bernardino Raquel , Crisostomo Luis , Terzo Simona , Monteiro Mariana P. , Oliveira Pedro F. , Allegra Mario , Alves Marco

Metabolic and endocrine dysregulation induced by high-fat diet (HFD) can lead to decreased male fertility potential and have a negative impact on the offsprings metabolic health. Small non-coding RNAs (sncRNAs) were proposed as being potential mediators of metabolic queues across transgenerational inheritance. During development and epidydimal transit, spermatozoa become enriched with tRNA-derived stress-induced RNAs (tiRNAs). This sncRNAs class appears to be particularl...

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High-fat diet promotes 3’mt-tiRNA-Met epididymosome enrichment which correlates to lower spermatozoa mitochondrial translation

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